The science of growth factors as an anti-aging skin technology moved forward a great deal through the work of scientists Stanley Cohen and Rita Levi-Montalcini, who were awarded the Nobel Prize in Medicine in 1986 for advancing understanding of the role of Epidermal Growth Factor (EGF) in cell biology. Other researchers continued studying EGF, leading to current clinical applications of EGF for skin conditions and reversing the signs of aging. EGF is known to considerably increase skin cell regeneration, and studies have shown that it significantly aids in the healing of skin wounds.

Some researchers wondered if the same GF-technology that was bringing such remarkable healing results to skin injuries could bring about cosmetic benefits as well. Scientists found that GF-technology had the potential to reverse the cell aging process, fade scars, improve healing, and renew the hair follicles on the scalp to help people with thinning hair. GF-technology is now being shown to improve the appearance of aging and sun-damaged skin and to help restore normal hair growth. Cosmetic patents of early GF-technology were first issued in 1994.

Since the work of Cohen and Levi-Montalcini, scientific research has built a knowledge base of types and functions of other major GF, including TGF-b (Transforming Growth Factor), PDGF (Platelet Derived Growth Factor), GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor), and IL (Interleukins). Medical research has found that GF can speed and improve healing when applied to areas of the human body damaged in surgery, burns, wounds, or accidents. The mechanism behind the benefits is facilitation of changes at the cellular level to revert damaged cells to a younger state, healing the damaged skin in the process.

This burn study of 2006, affirmed the power of stem-cell derived growth factor applications, and laid the groundwork and the basis for our revolutionary products, which have been used to better the lives of many people.